The former Hull boss will be looking to bounce back from the disappointment of seeing his new side throw away a two-goal lead at Bradford on Friday as he took the reins following Paul Sturrock's departure.
Brown could be without midfielder Reeves and defender Prosser as the Shrimpers look to leapfrog Fleetwood in the table.
Reeves came off at half-time on Friday after picking up a calf problem while Prosser suffered a knock.
Defender Chris Barker (Achilles), midfielder Michael Timlin (broken leg) and striker Neil Harris (knee) are definitely out while Mark Phillips (broken toe) is unlikely to feature despite returning to training.
- Sports & Recreation
- Paul Sturrock