Skipper Jackson and fellow midfielder Hughes missed last weekend's 2-2 draw at Middlesbrough after tweaking their hamstrings against Wolves the week before, but the injuries are not serious.
Defender Leon Cort remains doubtful with knee trouble but boss Chris Powell has no new injury concerns.
Powell admits he may make one or two changes and add a youngster or two to the bench for the final game of the season.
Rookie striker Michael Smith scored four for the reserves in midweek so he could be involved.
The Addicks have won their last three home games and are guaranteed a top-half finish in their first season back in the Championship.
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- Chris Powell