Pugh, a regular in the Cherries side that has climbed to the top of the npower League One table, has been suffering this week and missed the victory over Crewe.
Stand-in captain Tommy Elphick is likely to miss out again with a knee injury sustained in the victory over MK Dons.
Fellow defender Charlie Daniels has missed the Cherries' last four matches with a persistent foot problem and looks like missing out again, with Matt Ritchie set to deputise at left-back once more for Howe's men.
Daniels could be ruled out for the rest of the season if he needs to undergo an operation to cure the problem.
Scottish winger Ryan Fraser was back on the bench on Tuesday having been missing since his move from Aberdeen last month and is likely to be involved again as the Cherries look to win their sixth successive match.
- Sports & Recreation
- Charlie Daniels
- Tommy Elphick