The Alex expect to have a similar squad to the one which was beaten 2-1 by Leyton Orient on Saturday and Ikpeazu, borrowed from Watford, could be in line for his start since moving to Gresty Road.
Another hoping to lead the line will be Mathias Pogba, still working his way back slowly from a pre-season knee injury, but a similar ailment is likely to keep defender Ollie Turton out, although he is at least back in training.
Teenager Ryan Colclough (stomach) and fellow forward Max Clayton (ankle) remain long-term absentees.
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- Leyton Orient
- Mathias Pogba