Defoe played some of the best football of his career before Christmas, finding the net 13 times to silence the doubters who claimed he was no longer good enough to cut it in the Premier League.
The 30-year-old went through a 12-game dry patch, but he looked back to his best on Sunday as he came off the bench to help inspire Tottenham to come from behind and beat Manchester City 3-1.
Emmanuel Adebayor's erratic form had led to fears that Spurs would not have the firepower to keep up with rivals Arsenal and Chelsea in the run-in, but Defoe's return gives Villas-Boas a welcome selection headache ahead of Saturday's trip to Wigan.
"Yes, it's a big decision (to choose between Defoe and Adebayor), but we are extremely happy," Villas-Boas told a press conference.
"It's very important for us to have Jermain back, particularly because he found the back of the net.
"Goalkeepers have been making impossible saves against him and he finally got the ball in the net the other day with a tremendous goal that helped us get the three points.
"It's good because he had a blip in terms of goals, not performances - he was always sharp - but he had a couple of injuries. Now he is back he gives us that quality and confidence by scoring."
Prior to last Sunday, Spurs' form looked to be deserting them in the final straight, just as it had done for the previous two years. The win over last year's champions has given the squad a boost in morale, however.
"It was inspirational," the 35-year-old said. "Hopefully with the motivation we had from that game we can get the result we want this weekend and for the rest of the season."
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- Emmanuel Adebayor