Midfielder Sweeney and defender Horwood have missed the last two matches due to respective hamstring injuries and manager John Hughes must decide whether to recall them to his starting line-up.
Hughes has no new injury or suspension problems, but striker James Poole is still struggling with a leg injury and is expected to miss out.
Midfielder Greg Rutherford is likely to be included again despite sustaining a head injury for the reserves in midweek.
Another teenager, forward Zak Boagey, made his first appearance for the club as a late substitute in last week's win over Bury and hopes to feature again.
Pools, five points from safety with three games remaining, are chasing back-to-back successes after ending an eight-game winless run last week.
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