Republic of Ireland Under-19 international Drennan stepped off the substitutes' bench in the weekend defeat to Colchester after arriving from Aston Villa in a month-long deal last week.
Defenders Conor Townsend (foot) and Chris Chantler (ankle) remain sidelined, while the Cumbrians will also be without influential centre-half Max Ehmer, who has been recalled by parent club QPR.
Boss Graham Kavanagh is short on defenders as Danny Livesey is struggling with a calf injury, while midfielder Paul Thirlwell is still out with a similar problem. Carlisle have lost five of their last six matches.
- Sports & Recreation
- Aston Villa
- Chris Chantler
- Conor Townsend
- Danny Livesey