Former Aldershot defender Winfield, who missed Tuesday's 0-0 draw with Northampton has a calf problem, while 11-goal McClure sustained a knee injury in the stalemate.
If their skipper fails to make it then Leon Johnson could deputise once more while Junior Morias and Sam Wood will both be hoping they get the nod to replace McClure.
Stuart Lewis returned to the Chairboys' starting line-up against the promotion hopefuls following his two-match ban and he is expected to keep his place in Gareth Ainsworth's side.
Kortney Hause looks set to be on the bench more having returned to the matchday squad after illness but Anthony Stewart, Matt Bloomfield, Danny Foster and Grant Basey remain sidelined.
- Sports & Recreation
- Junior Morias
- Leon Johnson