Van Persie left Arsenal for Manchester United in the summer and has proved the major difference in this season's title race, taking his tally to 24 Premier League goals with Monday's hat-trick against Aston Villa.
But his appearance in north London this weekend is unlikely to go down well with the Arsenal fans who felt he had let them down by leaving in the summer.
"I don't bother about it, and I don't think Robin should bother about it either," said Ferguson.
"There was a bit of booing when he played at Old Trafford and I expect a portion of fans will do that.
"That is the modern generation I am afraid."
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