Midfielder Frampton saw red in the late stages of Tuesday's 1-1 draw at Rochdale and now misses the next three games as the Gills aim to consolidate their lead at the top of the npower League Two table.
Chris Whelpdale was forced off midway through the first half at Spotland and now faces a fitness battle, as does his replacement Charlie Lee.
Matters went from bad to worse in midweek as fellow midfielder Bradley Dack was then substituted due to injury after the break.
Forward Myles Weston will also again be assessed having missed the last five matches with an ankle problem, while Gillingham have been unable to extend Michael Richardson's loan spell and he has now returned to Newcastle.
- Sports & Recreation
- Chris Whelpdale