Hughes last featured for the Shakers in January before joining Accrington on loan, making five appearances, but suffered a calf injury that it was initially feared would end his season.
The 26-year-old defender will be pressed into action after Efe Sodje collected his 10th booking of the season - three of those accrued during a loan stint at Barrow - in last weekend's 2-0 loss at Hartlepool that means defeat to Latics will condemn Kevin Blackwell's men to the fourth tier.
Craig Fagan received a straight red card at Victoria Park and, although Tom Soares (hamstring) has resumed training once more, Blackwell is once again facing the prospect of not naming a full complement of substitutes due to a raft of long-term absentees.
"The situation with injuries is dire," he said.
"Sodje's out suspended and so is Fagan so we might have a couple on the bench. Tom Soares is okay, he's trained (on Thursday)."
- Sports & Recreation
- Efe Sodje
- Kevin Blackwell