Laird, who turned his loan switch from Leyton Orient into a permanent deal on Friday, sits out at the Kassam Stadium having played earlier in the competition for his former club.
On-loan striker Britt Assombalonga will be assessed ahead of the tie having missed Saturday's 2-2 FA Cup third-round draw at home to Brentford with his troublesome ankle and shin injury.
However, should Assombalonga even be passed fit then he will face a tough ask regaining his starting spot after Barry Corr stepped in and bagged a brace against the Bees to rescue an FA Cup replay.
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