McCombe was forced off late in the second half of the 1-1 home draw against Aldershot with a groin injury.
It prompted fears that the 27-year-old might miss the remainder of the promotion run-in, but he trained on Thursday and looks set to make Saturday's clash.
Fellow centre-half Liam Chilvers missed Tuesday night's match due to a groin problem and he will be checked.
"We will have to assess Liam Chilvers. Hopefully it won't be as bad as we first feared and he will be available for selection on Saturday," said Vale boss Micky Adams.
"Having said that, we have got young Joe Davis or Richard Duffy we can stick in there so it is not the end of the world if those two aren't fit."
Adams also has the likes of Louis Dodds, Chris Shuker and Ben Williamson to call upon should he wish to freshen up his starting XI.
Ashley Vincent could also be in the squad at Spotland, but Calvin Andrew has been ruled out.
Winger Vincent, who has been sidelined for a month with an ankle injury, resumed training this week. However, striker Andrew has a knee problem and he joins Rob Taylor (Achilles) on the absentee's list.
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