Blues were already 2-0 ahead courtesy of early goals from Samuel Eto'o and Andre Schurrle when Alex Oxlade-Chamberlain handled an Eden Hazard shot and Marriner instead showed a red card to Kieran Gibbs, despite his team-mate apparently approaching the referee to admit wrongdoing.
Hazard netted from the resultant penalty, Oscar added a fourth before the interval and a fifth before his replacement Mohamed Salah netted his first Chelsea goal and the Premier League leaders' sixth.
The Portuguese said: "We came to kill and in 10 minutes we destroyed (them). Ten amazing minutes, no doubt this game was our game.
"After that, easy. Penalty, red card, 3-0. Easy. But my analysis of the game is about the 10 minutes.
"The penalty was a penalty and the red card was a red card. It's the kind of mistake that no referee wants to make."
Mourinho is an advocate of the fourth official having access to a screen to replay decisions.
He added: "It would be nice for the ref because he doesn't want to make that mistake, it would be nice also for the players that a little screen could say Chamberlain, not Gibbs."
Mourinho insists his side's title chances remain slim as Manchester City have games in hand to overtake the Blues.
And it is clear the Portuguese is still seething at last week's controversial loss at Aston Villa, when referee Chris Foy sent off Willian, Ramires and the Chelsea boss.
He said: "Can we play against Aston Villa again? No.
"The momentum was broken last Saturday. Somebody broke the momentum and now we are trying to build another momentum."
Mourinho gestured with his finger and thumb to show his side have "just a little" chance of the title.
- Sports & Recreation
- Kieran Gibbs
- Andre Schurrle
- Alex Oxlade-Chamberlain