Mvoto missed Saturday's 2-1 home defeat to Crewe after picking up five bookings for the season and being forced to serve a one-match suspension.
Reece Wabara filled in a centre-half in his absence and the on-loan Manchester City youngster is expected to revert to his more familiar position of right-back, with Connor Brown the most likely candidate to make way for Mvoto.
Robbie Simpson will serve the third and final game of his suspension for a red card in 4-1 loss at Yeovil, meaning Jose Baxter and Matt Smith are set to continue in attack with weekend goalscorer Daniel Taylor likely to feature from the bench once more.
A run of four consecutive npower League One defeats means Paul Dickov's men head into the match only six points ahead of second-bottom Scunthorpe.
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- Robbie Simpson