His side travel to face current Barclays Premier League leaders Manchester United on Wednesday night, and the Argentinean is targeting all three points.
"Every game is important, every single match we play is important to us," he said.
"No doubt they are going to be tough and complex games against Manchester City and Manchester United but all games are like that.
"All games are key and the glamour factor does not dictate how we play, the main thing is that we go out with a winning mentality and we want to win every single game, we always respect our rivals but our aim has to always be to get the three points."
Club captain Adam Lallana could be fit enough to make the bench for the game against United and Pochettino says he will not rest key players with one eye on a crucial relegation clash with Wigan on Saturday.
"Lallana may play, he has been training well and looking okay so he may get some minutes against Manchester United so we will see how that develops," he said.
"We're going to Manchester to win and that has to be our mentality and I'm going to chose the players that will do that for us and for the team.
"Every single game represents three points whether you are playing against Manchester United, Wigan, Man City or Newcastle."
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