A hip problem saw Little substituted just before half-time against Shrewsbury on Saturday and the full-back will undergo a late fitness test. However, midfielder Grant McCann is not expected to recover from his slight groin injury.
Winger Nathaniel Mendez-Laing, who scored the winning goal in Posh's 1-0 victory over the Shrews, is pushing for a starting place against the side where he spent a short period on loan last season while Lee Tomlin could be included among the substitutes after making good progress in his recovery from an ankle injury.
Darren Ferguson's side go into the game on the back of six straight Sky Bet League One wins and four clean sheets and are just one point adrift of table-topping Leyton Orient.
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