Rooney has been given permission to sit out the trip as wife Coleen is due to give birth to the couple's second child.
The 27-year-old's Old Trafford future is in doubt after he asked for a transfer recently.
Sir Alex Ferguson has now passed that matter on to new manager David Moyes to deal with.
However, after being left out of Ferguson's final home game before retirement last week, Rooney will also miss the Scot's final one ever as a manager at The Hawthorns on Sunday afternoon.
- Sports & Recreation
- Sir Alex Ferguson