The on-loan midfielder has only recently returned from a troublesome hamstring complaint, but suffered a recurrence of the same injury on New Year's Day as the Saddlers beat Stevenage 1-0.
Cuvelier has now returned to parent club Stoke for treatment and will be sidelined for the short-term at least, with the injury expected to keep him out beyond his scheduled loan stay, which runs until mid-January.
Andy Taylor will miss out against Pompey with the groin strain which also forced him off against Boro, although the problem is not serious.
Fellow defender Dean Holden continues to be sidelined with his ankle problem, again a minor complaint, but forward Febian Brandy does return having served his one-match suspension.
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