The 17-year-old picked up a ligament issue ahead of his England Under-21s debut against Sweden in midweek, while fellow full-back Nathaniel Clyne, another to drop out of the Young Lions' squad, may also be unavailable.
Gaston Ramirez and Guly do Prado are also possibly out, while Jose Fonte is sidelined. Adam Lallana could make his first start since suffering a knee injury on December 8 and January acquisition Vegard Forren could make his debut.
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- Nathaniel Clyne