Smith will begin a four-match ban at the weekend following his red card in the FA Cup defeat to Barnsley last Saturday.
However, fellow forward Ryan Lowe and defender Antony Kay come back into the squad after completing their respective suspensions.
Manager Karl Robinson, who lost his chief scout Alex Rae to former Dons boss Paul Ince at Blackpool this week, will also have Izale McLeod available again after the striker was cup-tied against the Tykes.
However, forward Dean Bowditch is out with a groin injury and joins midfielder Stephen Gleeson on the sidelines as he continues his recovery from a broken foot.
- Sports & Recreation
- Ryan Lowe
- Antony Kay