Spence has rejoined the Dons on loan until the end of the season. The West Ham defender played 12 games for Karl Robinson's side in his first spell at stadiummk earlier this season, the last of which was a goalless home draw with Colchester on New Year's Day.
The versatile 23-year-old, who can play at right-back or centre-back, should partner Antony Kay in the centre of defence on Saturday.
Elsewhere, the Dons have no fresh injury concerns after both Lee Hodson (knee) and Dele Alli (leg) both returned to action in the midweek defeat at Carlisle.
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- Karl Robinson