Manager Paul Sturrock is refusing to reveal the identities of the quartet concerned but all four are doubts having been involved in Saturday's 1-1 draw against Torquay.
Defender Ryan Cresswell is another who will be assessed as late as possible having missed out altogether at the weekend with a calf injury, while Luke Prosser serves the second game of his two-match suspension and Mark Phillips (broken toe) and Chris Barker (Achilles) are nowhere near returning.
However, striker Barry Corr is expected to be available having missed out against the Gulls due to illness.
Midfielder Matthew Lund played the final game of his current loan spell at the weekend but boss Sturrock is confident of extending his stay from Stoke.
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- Ryan Cresswell