The Grecians have lost their last four games on the bounce, a run that has seen them slip out of the npower League Two play-off places, and Tisdale is expected to ring the changes in a bid to reverse the club's fortunes.
Striker John O'Flynn, who was dropped to the bench for Tuesday's 4-1 defeat against Rotherham, is in contention to return to the starting XI.
Long-term absentees Matt Oakley, Alan Gow, Myles Anderson and Liam Sercombe are out, while Kevin Amankwaah (ankle) remains doubtful.
Tisdale will check on defender Steve Tully (broken toe) ahead of kick-off and is likely to stick with Aaron Dawson at right-back if Tully is not ready to return.
- Sports & Recreation
- Myles Anderson
- Matt Oakley