Barnsley winger Noble-Lazarus missed the midweek FA Cup replay defeat to Grimsby as he was refused permission to play by his parent club.
Scunthorpe, who sacked manager Brian Laws on Wednesday, are also hoping to recall Eddie Nolan to the squad. The right-back has been sidelined since September with a hamstring injury but played 90 minutes for the reserves in midweek.
Midfielder Matt Sparrow is still out due to a similar problem as the Iron chase their first win in six matches.
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