The striker, who has just returned from a three-match ban, was carried off on a stretcher during Tuesday's draw against Sheffield Wednesday with a broken bone in his foot and could be out until December.
He joins Craig Mackail-Smith (Achilles) and Will Hoskins (knee) on the sidlelines meaning Ashley Barnes is once again the Seagulls' only available forward.
Andrew Crofts (hip) is available but fellow midfielders Liam Bridcutt (hernia) and Andrea Orlandi (knee) are struggling with injuries.
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- Ashley Barnes
- Sheffield Wednesday