The Manchester United boss has confirmed Anderson, Nani and Antonio Valencia will miss the Etihad Stadium encounter.
In addition, Ferguson has claimed the game will come too soon for Japan forward Shinji Kagawa and that skipper Nemanja Vidic is unwilling to risk another setback after spending virtually 12 months on the sidelines with major knee problems.
Yet Ferguson does not view the absences as a handicap, more of a predictable inconvenience ahead of a big game.
"I know we have some injury problems but we are not short of a squad," Ferguson told MUTV. "I have plenty of experience to bring in. I rested Darren Fletcher against Cluj on Wednesday and just brought him on for the last 10 minutes.
"Michael Carrick will be back in. I also have Ashley Young, Wayne Rooney, Robin van Persie, Danny Welbeck and Javier Hernandez.
"That is what big squads allow you to do. You don't have every player every week. Our supporters must recognise that.
"Over the years we have had injury situations. Every club gets them. Normally you work on 10% of your squad being out every week with some sort of injury.
"That is the situation we are in at the moment but it is not desperate by any means."
- Sports & Recreation
- Shinji Kagawa
- Antonio Valencia
- Nemanja Vidic