Van Persie, who moved to Old Trafford from Arsenal last summer, has scored 25 goals so far this term to help United win their 20th Barclays Premier League title.
He is joined in the Team of the Year, which is voted for by the players, by team-mates David De Gea, Rio Ferdinand and Michael Carrick.
Deposed champions Manchester City only have one member in the team - Argentina right-back Pablo Zabaleta.
Controversial Liverpool striker Luis Suarez, who last week received a 10-match ban for biting Branislav Ivanovic, partners Van Persie up front in the XI, which was revealed at a glitzy bash in central London on Sunday night
Gareth Bale's 19 goals earn him a place in the team, while his Tottenham team-mate Jan Vertonghen is named in central defence. Chelsea duo Juan Mata and Eden Hazard were also included, as was Everton left-back Leighton Baines.
Premier League Team of the Year: David De Gea (Manchester United), Pablo Zabaleta (Manchester City), Jan Vertonghen (Tottenham), Rio Ferdinand (Manchester United), Leighton Baines (Everton), Michael Carrick (Manchester United), Juan Mata (Chelsea), Gareth Bale (Tottenham), Eden Hazard (Chelsea), Luis Suarez (Liverpool), Robin van Persie (Manchester United).
Championship Team of the Year: Kasper Schmeichel (Leicester), Kieran Trippier (Burnley), Wes Morgan (Leicester), Mark Hudson (Cardiff), Wayne Bridge (Brighton), Wilfried Zaha (Crystal Palace), Thomas Ince (Blackpool), Peter Whittingham (Cardiff), Yannick Bolasie (Crystal Palace), Glenn Murray (Crystal Palace), Matej Vydra (Watford).
League One Team of the Year: Wesley Foderingham (Swindon), Simon Francis (Bournemouth), Robert Jones (Doncaster), Harry Maguire (Sheffield United), Charlie Daniels (Bournemouth), Matthew Ritchie (Bournemouth), Luke Murphy (Crewe), Alan Judge (Notts County), David Cotterill (Doncaster), Patrick Madden (Yeovil), Leon Clarke (Coventry).
League Two Team of the Year: Stuart Nelson (Gillingham), Sean Clohessy (Southend), Adam Barrett (Gillingham), Ryan Cresswell (Southend), Joseph Martin (Gillingham), Jacques Maghoma (Burton), Marlon Pack (Cheltenham), Gary Jones (Bradford), Jennison Myrie-Williams (Port Vale), Tom Pope (Port Vale), Jamie Cureton (Exeter).
- Sports & Recreation
- Manchester United
- David De Gea
- Michael Carrick
- Pablo Zabaleta
- Rio Ferdinand
- Luis Suarez
- Gareth Bale