Vaughan started on the bench in Saturday's goalless draw with Sheffield Wednesday having recently returned from a seven-game lay-off due to a thigh strain.
The former Norwich forward is also one booking away from suspension and manager Simon Grayson did not want to risk losing him for the testing New Year's Day trip.
Grayson, who made five changes against Wednesday, is expected to retain Anthony Gerrard and Joel Lynch at the heart of defence, while Calum Woods and Danny Ward are hoping to return after knocks kept them out of the squad altogether at the weekend.
Alan Lee is available again following his three-match ban, but may have to settle for a place on the bench alongside fellow striker Lee Novak, while Oliver Norwood is pushing for a recall to midfield as Huddersfield chase their first win in 10 league matches.
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- Simon Grayson