Winger Zaha, a transfer target for a host of top clubs this month, limped out of last weekend's FA Cup draw against Stoke after taking a nasty whack on the ankle.
Striker Murray, the Championship's top scorer this season with 22 goals, missed the third-round tie through illness.
Manchester City forward Alex Nimely will travel with the squad after joining on loan until the end of the season, while Julian Speroni will return in goal after he was rested against the Potters.
Danny Gabbidon is a doubt with a hamstring problem, fellow defender Paddy McCarthy remains sidelined by a long-term groin injury and midfielder Kagisho Dikgacoi is on African Nations Cup duty in South Africa.
- Sports & Recreation