The 25-year-old was in action one final time at the capital's Basketball Arena, hoping to help Great Britain end on a high note in their final preliminary game with a quarter-final spot already out of their reach.
And on paper this would be their best chance as they faced off against Brazil, a side that had also lost their first four games.
But despite finding themselves just three points behind at half-time, a second-half blitz from Brazil meant Great Britain suffered another loss, going down 78-66.
However, Handy is remaining confident that all is not lost, adamant that the showing she and her team-mates put on in the capital on their Olympic debut shouldn't go to waste.
"Brazil were fast and they were strong and it was a difficult and tough game," said the Consett-born player.
"We scouted them a lot going into the game and we thought we could have beat them but I think we just needed a bit more momentum then we had.
"So with all that in mind it is a tough loss to take because we were looking at the Brazil game as one we could win and we haven't managed that.
"But one of the things we were looking to do going into London was to put basketball on the map and I think we have done that.
"Hopefully we can get more people playing and get people supporting us and as a sport get it out there.
"We have done ourselves proud I think. We have hung in there, we haven't been embarrassed by teams and hopefully it is just onwards and upwards and get better as a nation and be in a better position come the next Olympics."
Despite failing to record a victory at London 2012, Handy and co were cheered on game after game as the British public got behind the team.
And Handy insists having that kind of support all year round off the court would make a huge difference to the team's fortunes on it.
"I cannot say enough good works and thank the crowd enough for the support we received, it has been amazing," she added.
"Even though we weren't getting the results for them they cheered every point and stuck with us through it all.
"I hope this kind of support stays because we need it if we are to help the sport grow and it really does make a huge difference."
- Sports & Recreation