Brown, the Colts' leading rusher this season with 60 carries for 239 yards and one touchdown, had surgery on Tuesday after injuring his knee on his final play in Sunday's 30-27 upset win at home against the Green Bay Packers.
Interim Indianapolis coach Bruce Arians told reporters on Wednesday the initial timetable on the 25-year-old's return was two to three weeks.
Rookie running back Vick Ballard will make his first National Football League start on Sunday when he replaces Brown in the Colts lineup against the New York Jets. (Reporting by Mark Lamport-Stokes in Los Angeles; Editing by Frank Pingue)
- Green Bay Packers