Goals from Tom Flanagan (22), Matt Fish (40), Myles Weston (59) and Joe Martin (63) handed the league leaders a comfortable win against a Burton side who saw their eight-game unbeaten run end despite Zander Diamond's effort in the 54th minute.
Port Vale remain firmly in the hunt after a Tom Pope double - who has now netted 15 times this term - saw them club Wycombe 4-1 at home.
Vale fell behind to a Joel Grant penalty on 20 minutes before four goals in the second half - with Jo Kuffour sent off for a second yellow card - was more than enough for the home side. Ben Williamson (59) and Ashley Vincent (90) struck either side of Pope's goals (66, 87).
Fleetwood lost ground after being held to a 1-1 draw by AFC Wimbledon, Byron Harrison cancelling out Steven Gillespie's 10th-minute opener just after the hour mark.
Bradford ended a four-game run without a win by beating Cheltenham 3-1 to climb to fifth and within a point of their opponents.
Marlon Pack gave the visitors the lead with a 29th-minute penalty but Nahki Wells levelled, also from the spot, on the stroke of half-time and City went on to win it with a second from Wells (68) and one from James Meredith (83).
Sixth-placed Exeter have now lost five of their last six games after Chris Atkinson (32) earned Chesterfield a 1-0 win while Rochdale dropped out of the top six following a 3-1 defeat by Plymouth.
A Guy Madjo penalty and a header from Andres Gurrieri put the hosts two up inside seven minutes and Bobby Grant missed a penalty (55) before Dele Adebola (76) did pull one back. Madjo made sure with a second penalty in injury time.
Rotherham secured a 3-0 victory away at struggling Aldershot with goals from Lee Frecklington (34), Robert Harris (56) and Alex Revell (82).
Struggling Bristol Rovers gained a valuable three points in a 3-2 victory over 10-man Torquay. Tom Eaves (15) and Matthew Lund (17) put Rovers two up before Joe Oastler was sent off for a second yellow card.
Torquay defied their numerical disadvantage to level through Rene Howe (53), scoring for the seventh straight league game, and Aaron Downes (59) but Eaves popped up with the winner 14 minutes from time.
Morecambe left it until two minutes from time to net the winner against Southend, Jack Redshaw earning a 1-0 win, although the match ended on a sour note when Richard Brodie was dismissed for violent conduct.
The biggest winners of the day were Oxford, for whom Tom Craddock scored the opening four goals (12, 23, 36, 71) in a 5-0 victory over Accrington. Alfie Potter grabbed the fifth 12 minutes from time.
York were the division's other winners, 3-2 against Dagenham & Redbridge. Ashley Chambers' opener (19) was quickly cancelled out by Luke Wilkinson (23) but Chambers (37) and Matty Blair (65) restored the advantage before Wilkinson netted a late consolation.
- Myles Weston