Cruyff, who represented the Catalan club 143 times, scoring 48 goals, and managed them for eight years until 1996, thinks it is risky to build a team around two star players.
It will be seen as a highly controversial perspective from the Dutch legend given that Messi has scored no fewer than 215 goals in 246 games at Barcelona, but he is adamant that there will be a clash if Neymar and the Argentine join forces.
"With Neymar on board, I would have planned for the possibility of selling Messi, and some would agree with that, others not,” Cruyff told Spanish newspaper Marca.
"You are talking about a team, its players, the things around it. There are too many things at stake. That’s why it’s so difficult to manage such a top class squad.
Asked if he would have signed Neymar in the first place, Cruyff added: "No, I wouldn’t have signed Neymar. We’ll have to wait and see – it could turn out well or badly. It’s a risk.
"It’s like the free kicks. Neymar is very good at taking them, and Messi has already shown he is. Who’s going to take them?
"Or the fact that Neymar and Barcelona are with Nike while Leo is with Adidas. These are situations that could cause problems.
"We’ll have to wait and see. He is talented but we’ll have to see how he gets on with everyone – that’s a problem."
- Sports & Recreation