A half-cleared cross fell to midfielder Sevilla after nine minutes at the Villamarin, and his first-time shot was too powerful for visiting keeper Diego Alves.
Valencia, still seeking their first away win this season, improved in the second half when striker Roberto Soldado, who scored a hat-trick against BATE Borisov in the Champions League during the week, twice went close.
Betis keeper Adrian blocked another Soldado effort with his legs in the closing minutes to leave Valencia ninth in the table with 11 points.
- Sports & Recreation
- Roberto Soldado
- Diego Alves