The French midfielder had to leave the pitch after just seven minutes of Saturday's 2-2 draw against derby rivals Portsmouth after suffering a knee injury.
Jack Cork came on for Schneiderlin and could start at Selhurst, although Richard Chaplow provides another option.
Full-back Frazer Richardson and top scorer Rickie Lambert shook off their recent injuries to play the full 90 minutes against Pompey and they should keep their places assuming they have felt no after-effects.
Boss Nigel Adkins is likely to make one or two changes, so Dan Harding and Steve de Ridder could start while fit-again defenders Dan Seabourne (head) and Radhi Jaidi (knee) will hope to be involved.
Paul McShane could return to the Crystal Palace squad.
The on-loan Hull defender has missed the last two matches, defeats by Nottingham Forest and Birmingham, due to the hip injury he suffered against Doncaster.
McShane was rated 50-50 to travel to St Andrew's on Saturday only to miss out.
His return would be a major boost to an Eagles side missing fellow centre-half Anthony Gardner (hamstring) and midfielder Mile Jedinak (groin) for the rest of the season.
Midfield duo David Wright and Jonathan Williams, who have only recently recovered from long-term injury lay-offs, were also absent on Saturday.
Strikers Glenn Murray and Chris Martin could be promoted to the starting line-up.