Vikings coach Denis Betts made six changes to the side that beat Warrington 38-22 on Good Friday and saw his inexperienced line-up cut to pieces by the ruthless Giants.
Inevitably, skipper Danny Brough was at the heart of Huddersfield's impressive display, creating a hat-trick of tries for left winger Aaron Murphy and contributing 22 points on his own with a try and nine goals.
Scott Grix (two), Michael Lawrence, Luke George, Jamie Cording, Jermaine McGillvary and Shaun Lunt also crossed for the Giants, with Joe Mellor scoring a second-half try for the visitors.
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- Danny Brough