The 32-year-old prop, who made his 24th Super League appearance of the year in the Wildcats' season-ending 36-32 win over Castleford on Sunday, is rejoining the Centurions on a one-year contract for 2014.
Leigh coach Paul Rowley said: "We have signed a very athletic and fit player to add to our already hard-working pack for 2014."
Wilkes said: "I'm very excited about my move back to Leigh. I've kept an eye on developments at the club for a few months now and it's clear there is real ambition and the set-up at the club is first class."
- Sports & Recreation