The 21-year-old, on loan from Warrington, was forced off after a late shoulder charge from Scott Taylor in last week's derby defeat of Wigan.
O'Brien's availability will be especially welcomed by coach Nathan Brown with the half-back also important for his goalkicking.
Brown said: "He was a bit groggy the next day and he didn't train in the latter part of last week.
"He had his time off but he has trained now and he is fine."
Brown is not anticipating many changes for the game in France but utility man Lance Hohaia could return after being left out against Wigan following a spell on the sidelines.
Brown added: "All the guys who played in the Wigan game have trained and come through fine.
"Lance is fit and available now. He's definitely a possibility.
"He was in the 19 for Wigan but he'd missed that bit of footy and we probably went for guys that were more match-ready.
"But he's training really well and is ready for an opportunity."
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