England's clash with the cream of Super League's southern hemisphere talent will take place at the Halliwell Jones Stadium on Friday, June 14, which is on a blank weekend in the Super League fixture list.
Leeds hosted the inaugural Origin Game in 2011 while Huddersfield and St Helens were the venues for last year's two matches.
This year the Rugby Football League has decided to revert to a one-off fixture, which will be England's only competitive game before they face Australia in their opening match of the 2013 World Cup in October.
England coach Steve McNamara said: "It's a massive game for England and every English player who aspires to being involved in our plans for the World Cup.
"International Origin offers us a great opportunity to continue the progress we have experienced as a group over the last few years and take an important step towards the World Cup.
"However, it's not just about the World Cup: this is very much a fixture we will be looking to win.
"There is always a lot of needle between the England and Exiles players ahead of the Origin game and I'm sure that between now and then we will see a massive hunger to be involved in this fixture from every player in Super League."
The RFL will need to find a new coach for the Exiles following the appointment of former St Helens boss Daniel Anderson, who guided them to a shared series in 2012, as NRL referees chief.
Former Leeds and New Zealand coach Brian McClennan was in charge of the overseas team in 2011.
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