Blake Green hit a hat-trick against his former club, with Pat Richards contributing 28 points - including a first-half try - as the Warriors blew Rovers away with ruthless efficiency.
Wigan outscored Rovers by 15 tries to one as the Super League leaders laid down a marker in East Yorkshire.
Josh Charnley, Iain Thornley (two), Jack Hughes, Matty Smith (two), Chris Tuson (two), Sam Powell, Liam Farrell and Sam Tomkins also went over for the Warriors, with Greg Eden scoring Rovers' only try of the game.
Second-placed Huddersfield roared back to winning ways with an 11-try, 62-6 rout as Widnes paid a heavy price for fielding an under-strength team.
Skipper Danny Brough was at the heart of Huddersfield's impressive display, creating a hat-trick of tries for left winger Aaron Murphy and contributing 22 points on his own with a try and nine goals.
Scott Grix (two), Michael Lawrence, Luke George, Jamie Cording, Jermaine McGillvary and Shaun Lunt also crossed for the Giants, with Joe Mellor scoring a second-half try for the visitors.
Third-placed Warrington Wolves responded to their surprise derby defeat at Widnes Vikings with an ultimately convincing 54-20 victory over an inexperienced London Broncos outfit.
Leeds ended Catalans' unbeaten home record with a backs-to-the-wall 27-12 victory that saw them on the wrong end of the penalty count and down a man after the dismissal of Ryan Bailey in the 48th minute.
Catalans struggled in wet conditions as they continually dropped the ball at crucial times with Zeb Taia, Louis Anderson and Jamal Fakir all accountable with unforced errors. Kevin Sinfield led the way with 15 points in the Rhinos' superb victory, achieved in spite of Bailey's removal for a late shoulder high challenge on Thomas Bosc.
Joel Moon, Paul McShane and Jamie Jones-Buchanan crossed over for a try apiece for Leeds, while Leon Pryce an Bosc scored the Dragons' tries and the latter added two goals.
St Helens prop Josh Perry celebrated his first tries for the club as they overcame Super League's bottom side Castleford 48-18.
Bradford consolidated their position in the upper reaches of the Super League table with a deserved 36-24 victory over Salford.
Jamie Shaul marked his debut in style with a brace of tries as injury-hit Hull FC bounced back from their derby defeat on Good Friday with a 34-22 win at Wakefield.
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