And the Glasgow prop is also looking to go one better than their agonising defeat by South Africa in June when the Springboks visit Murrayfield on Sunday.
Low was named in Scott Johnson's team on Wednesday for his first start since the 2011 World Cup warm-up against Italy.
The 28-year-old did not play at all for his country in 2012 after being hit by a serious knee injury and all six of his previous appearances this year have come off the bench.
"It's fantastic to have the opportunity to start and go out there and show what I can do," Low said.
"It's great to test yourself out there against South Africa.
"There were injuries and selection issues but I had a good pre-season behind me and have been putting in good games for Glasgow and adapting to the new laws in the scrum. I have been really happy with my form and I want to take that on in a Scotland jersey."
Low came on during Scotland's summer defeat in Nelspruit in June. The visitors led 17-6 but South Africa scored the final 24 points of the game to turn the tables.
Low said: "They are a pretty big pack but we are a big side too. We have shown that in the past, the games we played here when we beat them and the game across in South Africa in the summer when we went toe-to-toe with them.
"They are always close matches but they are very physical and we need to bring that again on Sunday.
"Over there we felt we should have won the game. But it was that 80-minute performance that we didn't have.
"Against these teams you have got to be at your best for 80 minutes. For 10-15 minutes we weren't at our best and they took advantage of it. That's what clinical, world-class teams do."
Low believes Scotland need to maintain concentration and stick rigidly to their defensive system after conceding two early second-half tries in their 42-17 win over Japan on Saturday.
"A couple of times when Japan got their tries, a couple of people were out of the system," he said.
"As soon as someone goes out of the system, you are not all singing off the same song sheet.
"When you are all defending as a team and sticking to the system, everyone knows what they have got to do in those areas. When we go away from that, that's when we concede tries."
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