The 25-year-old is widely regarded as one of the top young players in his position in the country and will boost the options of the London club.
Mullan said: "I have had a great eight years at Worcester and leaving your home town club is always hard. However, I felt the time was right for a new challenge and I am looking forward to joining up with London Wasps next season."
He added: "As a club with lots of other aspiring young English players, I hope to be part of a successful side there in the coming years."
Mullan made his senior England debut in 2010 and toured with the squad to South Africa last year. He is currently part of the England Saxons line-up.
Wasps director of rugby Dai Young said: "Matt has achieved plenty in his career to date but I believe there is a lot more to come from him.
"He will add to our growing base of young English talent at London Wasps and we are pleased he will be with us from next season."
- Sports & Recreation
- London Wasps