The Springboks opened their Rugby Championship campaign with back-to-back victories over Argentina and while the second was far less convincing than the first, they arrived in Australia ranked number two in the world and ready for business.
The Wallabies, by contrast, have slid to fourth in the world, lost their first two matches of the tournament to New Zealand and then their captain James Horwill to a hamstring injury on Thursday.
South Africa still go into Saturday's Test (kickoff 1105 GMT) as underdogs by virtue of their relatively poor record on the road and having lost all seven matches against Australia at the arena where Wallabies coach Ewen McKenzie enjoyed the Super Rugby success that earned him his job.
Still looking for his first win, McKenzie has restored his former Queensland Reds charge Quade Cooper to the starting fly-half position after preferring Matt Toomua against the world champions.
Back in tandem with scrum-half Will Genia, who will captain the side in Horwill's absence, Cooper will be expected to ignite a back-line that largely failed to fire against the All Blacks.
To counter the expected aerial barrage from the Springboks, McKenzie has re-jigged his back three by moving Israel Folau to full-back, putting the hulking Nick Cummins on one wing and retaining James O'Connor on the other.
"It's a really full-on attack team, without talking them up too much, I truly believe it is one of the best back lines we have faced, not just this year," Springboks coach Heyneke Meyer said.
"They're going to move the ball with Folau at full-back, they'll attack our forwards on the blind. With Cummins coming in, I've always rated him, he is a very strong runner.
"And the one thing they'll look for is that their back three is very good under the high ball so they know how we're going to play and we know how they're going to play."
McKenzie agreed with Meyer that there would be few surprises.
"I think that they've been pretty consistent with how they've played the game, so there's a lot of certainty about how they go about their business," he said.
"They've got a lot of experienced players in key positions so that's been working for them.
"I don't think there's any confusion about how they go about it. Their formula works for them so that's how they do it, that's the Springbok way.
"We're in the process of working on how we want to do it - the Australian way - but it's a bit different so you've got a clash of rugby approaches but that's just the way it is."
Meyer has changed his own back three with full-back Zane Kirchner deployed for the first time this year after he recovered from a hand injury.
But a first start in more than a year for abrasive hooker Bismarck du Plessis and the continued selection of fly-half Morne Steyn might be a better indication of how Meyer is looking to break the Lang Park hoodoo.
"Away games will always be an arm wrestle," he said. "You get stuck in, you have to have your set phases at 100 per cent.
"You need good defence, to absorb the pressure and you need a 90-percent plus goal-kicker."
Australia: 15-Israel Folau, 14-Nick Cummins, 13-Adam Ashley-Cooper, 12-Christian Leali'ifano, 11-James O'Connor, 10-Quade Cooper, 9-Will Genia (captain), 8-Ben Mowen, 7-Michael Hooper, 6-Scott Fardy, 5-Kane Douglas, 4-Rob Simmons, 3-Sekope Kepu, 2-Stephen Moore, 1-James Slipper.
Replacements: 16-Saia Fainga'a, 17-Scott Sio, 18-Ben Alexander, 19-Ben McCalman, 20-Jake Schatz, 21-Nic White, 22-Matt Toomua, 23-Jesse Mogg.
South Africa: 15-Zane Kirchner, 14-Willie le Roux, 13-JJ Engelbrecht, 12-Jean de Villiers (captain), 11-Bryan Habana, 10-Morne Steyn, 9-Ruan Pienaar, 8-Duane Vermeulen, 7-Willem Alberts, 6-Francois Louw, 5-Flip van der Merwe, 4-Eben Etzebeth, 3-Jannie du Plessis, 2-Bismarck du Plessis, 1-Tendai Mtawarira.
Replacements: 16-Adriaan Strauss, 17-Gurthro Steenkamp, 18-Coenie Oosthuizen, 19-Juandre Kruger, 20-Siya Kolisi, 21-Jano Vermaak, 22-Pat Lambie, 23-Jan Serfontein.
Referee: George Clancy (Ireland)
- Sports & Recreation
- James Horwill
- Quade Cooper