The 32-year-old Leinster half-back will make his first Ireland start since March 2012 in autumn international action against the Wallabies in Dublin on Saturday after the team line-up was confirmed by the Irish Rugby Football Union.
Ireland head coach Joe Schmidt has favoured the former Wasps number nine in order to drive his side's tempo against the quick-witted visitors.
While Munster man Murray is an accomplished technician, 51-cap Reddan knows how to add impetus to a contest.
And against world-acclaimed Will Genia, former Leinster boss Schmidt believes that asset will be vital.
Ulster centre Luke Marshall has edged out experienced 12 Gordon D'Arcy in midfield, pairing up with Brian O'Driscoll to win his fourth cap.
Jonathan Sexton is fit to start as expected at fly-half, while lock Paul O'Connell captains the side from the second row.
O'Connell makes his first Ireland start since the 17-17 RBS 6 Nations draw with France in Paris in March 2012.
The 34-year-old new skipper will reprise his battle with gritty Wallabies lock James Horwill that was such a feature of the Lions' victorious tour Down Under in the summer.
Leinster's lofty 6ft 11in lock Devin Toner has won the battle to partner O'Connell, selected ahead of Mike McCarthy, who drops to the bench, and Dan Tuohy.
Cian Healy returns at loosehead prop, with Leinster club-mate Jack McGrath dropping to the bench.
Ian Madigan has been preferred to Paddy Jackson for the replacement fly-half berth, as much for his attacking acumen as his versatility in covering midfield and also full-back.
Sean O'Brien is fit to start at openside flanker, and will face an intriguing battle with Wallabies scavenger extraordinaire Michael Hooper.
Connacht back-three man Robbie Henshaw has forced out Dave Kearney for the final seat on the bench.
Kearney has been overlooked despite his two-try debut in last week's 40-9 victory over Samoa that opened both the autumn internationals and the Schmidt era.
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