Ryan led the side at 56 HSBC Sevens World Series tournaments, winning five titles and seeing England to third at this year's World Cup.
The 41-year-old will help the Rugby Football Union find his successor during the build-up to the HSBC Sevens World Series, which will get under way in Australia this October.
England will also need a new assistant coach as Russell Earnshaw is leaving to take up a teaching career in Economics at Eastbourne College next month.
"I've loved working as England Sevens head coach and enjoyed every minute in a time of dramatic change for the sport and the squad," Ryan told the official RFU website.
"In 2007 I met one player for the first time at the airport heading for a tournament; six years later we have a full-time England squad operating to the highest professional standards.
"We've been the leading northern hemisphere side throughout that period and we've recorded some great tournament victories - including eight individual wins over New Zealand - as well as reaching a World Cup final for the first time in 20 years. Eleven of our players have gone on to play for England at senior level in that time.
"As a coach your goal is always to leave something in better shape to pass on to the next generation and I believe that's been achieved."
England coach Stuart Lancaster believes Ryan will go on to achieve plenty more in the game.
"Ben's made a major impact on and off the field in developing our sevens programme and making sure the team achieves high standards in international competition," he said
"He's a first-class coach who has helped his players fulfil their potential and many of them have benefited from his guidance on the way to senior international honours.
"I'm sure he will go on to achieve more great things and wish him all the best for his future career."
- Sports & Recreation