Head coach Jon Callard has brought Gloucester's Jonny May onto the right wing in place of Christian Wade, and Matt Mullan will take over from Nick Wood at loosehead prop.
England's second string were beaten 35-0 in this fixture last year.
"If you don't get it right at international level, sides like this Scotland one will punish you heavily and that's what happened last year," Callard said.
"We've all learned from that and we're determined to get it absolutely right this time round.
"We put in a really gritty performance against Ireland and to win over there was a deserved reward for all that hard work."
Leicester number eight Jordan Crane captains the team.
England Saxons team: E Daly (Wasps); J May (Gloucester), J Tomkins (Saracens), J Turner-Hall (Harlequins), T Biggs (Bath): G Ford (Leicester), R Wigglesworth (Saracens); M Mullan (Worcester), J Gray (Harlequins), P Doran-Jones (Northampton), G Kitchener (Leicester), G Robson (Harlequins), G Kruis (Saracens), W Fraser (Saracens), J Crane (Leicester, captain).
Replacements: R Buchanan (Harlequins), N Wood (Gloucester), K Brookes (Leicester), E Slater (Leicester), J Gibson (London Irish), J Simpson (Wasps), G Lowe (Harlequins), K Eastmond (Bath).
- Sports & Recreation
- Jon Callard