It was a chastening loss for Andrew Gale’s depleted side, who could only muster a paltry 96 for nine off their 20 overs after losing early wickets and never being able to recover.
The Sixers coasted to their victory target with over 11 overs remaining as former England World Twenty20 winner Michael Lumb ended up on 43 not out, while captain Brad Haddin scored 41.
"150-160 would have been a good score," Gale said. "But we didn't get off to a good start, and we were chasing the game from thereon.
“We have learned valuable lessons from today, have three games left, and will hopefully reverse the result on Thursday."
Haddin said: “We had a few things we needed to work on after the first game. The best thing about the three fast bowlers was they bowled differently, presenting different challenges to the batsmen.
“I am pretty lucky they are all looking to have a go. We’ve still got to get better and better as the tournament goes on."
Sydney are now all but through to the semi-finals with eight points on the board after two victories in Group B, with the Cape Town Lions in second.
An abysmal net run-rate will now further compound Yorkshire’s beleaguered status at the bottom of the standings.
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