The 22-year-old midfielder is rated as 50-50 by boss Paul Tisdale as he nears a return from an ankle injury.
Sercombe picked up the injury in the 1-1 draw with York and has missed the last four matches, but the Grecians hope to have him available to bolster their depleted midfield.
Striker Alan Gow missed the game with an ankle injury but could also return to contention as Exeter look to leapfrog second-placed Vale in the League Two table.
Tisdale is already without Scot Bennett, who is out with a leg injury, while Matt Oakley and Tommy Doherty are nursing knocks picked up during Tuesday's 2-1 victory over Barnet.
Meanwhile, Chris Neal will continue in goal for Port Vale, who currently find themselves in fourth place, just a point behind their opponents.
Neal, at fault for Dagenham's goal in the lacklustre 1-1 home draw in midweek, took a blow to the face earlier in that game in a challenge with visiting striker Sam Williams.
Adams made one change against Dagenham as Sam Morsy was brought back into central midfield and skipper Doug Loft reverted to left-back, meaning no place for Rob Taylor.
Taylor, along with Adam Yates, Gareth Owen, Chris Shuker, Ben Williamson and Ryan Lloyd are options for Adams should the Vale boss wish to make any changes to his starting XI.
- Paul Tisdale