The Belarusian has been plagued by a problem with her left foot for the past month but played through the pain. Now, however, she says she needs to take a break to get it healed.
"I love playing in the US and my results in the past were also great. But it's now been over a year that it seems bad luck has been following me," she said in a statement released by the Women's Tennis Association.
"I couldn't play in Miami last year with a problem in my ankle and now this with my foot. It is time for me to think about my recovery and I will work hard for that."
Azarenka's foot problems flared up at the Australian Open in January, where she was attempting to win the title for the third year in a row.
The Sony Open, one of the biggest tournaments outside the Grand Slams, has long been one of Azarenka's favourite events.
She won the title in 2009, beating Serena Williams in the final, then again in 2011 when she defeated Maria Sharapova.
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